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Synthesis of Aspirin derivatives

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        Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder. Aspirin is an oral non-steroidal anti-inflammatory drug (NSAID) that is rapidly absorbed from the stomach and the small intestine.  It is a non-selective NSAID as it irreversibly inhibits both cyclooxygenase (COX) enzymes involved in converting arachidonic acid to prostaglandins and thromboxane 3 . Prostaglandins are found throughout the body and are made to help manage injury or infection. Prostaglandins upregulate the sensitivity of pain receptors. As a control mechanism, they act locally at the site of synthesis which limits the extent of their activity. They are also broken down rapidly by the body. The enzymes that produce prostaglandins are cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), they have diverse roles and are wid...

Nanoscale nutrients can protect plants from fungal diseases

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In soybean plants, the  Fusarium virguliforme  fungus mottles the leaves (pictured) and leads to “sudden death syndrome,” a leading disease in North America that limits crop yields. Chances are, most , if not all of the produce in your kitchen is threatened by fungal diseases. The threat looms large for foo staples of the world such as rice, wheat, potatoes and maize . Pathogenic fungi are also coming for our coffee, sugarcane, bananas and other economically important crops. Annually, fungal diseases destroy a third of all harvests and pose a dire threat to global food security. To stop the spread of fungal diseases, farmers fumigate the soil with toxic chemicals that lay waste to the land, sparing not even the beneficial microbes teeming in the earth. Or they ply plants with fungicides. But fungicide use is effective only in the short run  until the pathogenic fungi evolve resistance against these synthetic chemicals. Now, a new idea is taking root: Help plants stand the...

Phytoremeiation of Heavy Metals

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Phytoremediation of Heavy Metals  

Chemistry Textbook for Grade X

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Chemistry Textbook for Grade X  

Chemistry IGSCE Textbook

IGSCE Textbook  

Chemistry IGSCE Textbook

Classified Chemistry

Synthesis of Aspirin derivatives as antimicrobial agent

Aspirin Presentation